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In the nested simulation literature, a common assumption is that the experimenter can choose the number of outer scenarios to sample. This paper considers the case when the experimenter is given a fixed set of outer scenarios from an external entity. We propose a nested simulation experiment design that pools inner replications from one scenario to estimate another scenario’s conditional mean via the likelihood ratio method. Given the outer scenarios, we decide how many inner replications to run at each outer scenario as well as how to pool the inner replications by solving a bilevel optimization problem that minimizes the total simulation effort. We provide asymptotic analyses on the convergence rates of the performance measure estimators computed from the optimized experiment design. Under some assumptions, the optimized design achieves [Formula: see text] mean squared error of the estimators given simulation budget [Formula: see text]. Numerical experiments demonstrate that our design outperforms a state-of-the-art design that pools replications via regression. History: Accepted by Bruno Tuffin, Area Editor for Simulation. Funding: This work was supported by the National Science Foundation [Grant CMMI-2045400] and the Natural Sciences and Engineering Research Council of Canada [Grant RGPIN-2018-03755]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0392 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0392 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .